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Abstract Methotrexate (MTX) is a folic acid reductase inhibitor that manages various malignancies as well as immune-mediated inflammatory chronic diseases

The participant is instructed to respond and push the target button as quickly as possible (CRT)

The dependent variables are calculated separately by the seconds required to complete the task for parts A (TMT-A) and B (TMT-B)

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It is a progressive disease

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