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The specific functional logic is as follows: In addition to GPR activation, SCFAs (especially butyrate) cross the blood-brain barrier via monocarboxylate transporter 1 (MCT1) and inhibit HDAC1/2 in the hippocampus and prefrontal cortexbrain regions critical for mood regulation
Great for metabolic support and endurance
AbbVie's pipeline includes pipeline peptide candidates in oncology and immunology, and its acquisition of ImmunoGen maker of the antibody-drug conjugate Elahere positions it in an adjacent targeted peptide-linker therapy space that bridges small molecules and biologics
Discovery, optimization, and evaluation of non-bile acid FXR/TGR5 dual agonists