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The tripeptide structure allows receptor binding at minimal concentrations because the interaction is highly specific

These experiments demonstrated that the gdh3 / gdh3 mutant was locked in the yeast morphology when proline was supplied as the sole carbon and nitrogen source

10.1016/S0039-128X(96)00093-1 92

That is a genetic-knockdown study in mice, not a drug trial: it tells you the target is real and metabolically meaningful in an animal model, but it does not test a drug, a dose, or a route

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More flexibility, better muscle tone, and reduced stiffness are common results