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Consistent with an induction of oxidative stress condition, metformin increased mRNA levels of the master redox transcription factor Nrf-2 (nuclear factor erythroid-derived 2-like), as well as transsulfuration enzymes cystathionine beta-synthase and cystathionase and GSH synthesis enzymes -glutamylcysteine synthetase and glutathione synthetase

The findings supported the broader hypothesis advanced by the Khavinson group across multiple studies that pineal-derived peptide bioregulators can modulate age-related decline in pineal gland function

L-Carnitine is an amino acid found naturally in the body that can help carry fat to the mitochondria

Cortisol and adrenaline lower sensory thresholds, making already-sensitive skin feel even more reactive

Data analysis The Comprehensive Meta-analysis software was utilized to process the data extracted from the included studies

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