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These factors collectively drive the progressive damage of biliary epithelial cells by autoantibodies, leading to cholestasis, fibrosis, and potential progression to cirrhosis or liver failure (217)

Transgenic and knockout analyses of the role of TNF in immune regulation and disease pathogenesis

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Notes: Data are presented as mean standard deviation and were analyzed by Students t -test

If the KLOW vial is 5+ mL in size rather than the standard 3 mL size, double the BAC water amount to 5 mL and syringe units (10 units for low / 20 units for standard / 30 units for elevated) for easier, more accurate dosing

The Royal College of Pathologists