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Conditions such as Crohns, coeliac disease or previous gut surgery, and the autoimmune cause behind pernicious anaemia, all affect how well you retain B12

The NIH reports that only about 10 micrograms of a 500-microgram oral supplement are actually absorbed in healthy people due to limitations of stomach acid and intrinsic factor

Most experienced researchers settle on 300-500mcg as the optimal daily dose

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Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification