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However, the modelling of chemical toxicology and in particular metabolic processes in vitro is fraught with many challenges, including the use of a proliferating rather than a quiescent cell, limited retention of metabolic activities in immortalised cell lines, and the poor recapitulation of the in vivo metabolic environment and substrate availability

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Hedgehog signaling has a protective effect in glucocorticoid-induced mouse neonatal brain injury through an 11HSD2-dependent mechanism

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The study found that the exosomal SP94-Lamp2bRRM, which targets HCC, aids in delivering small interfering RNA to improve sorafenib-induced ferroptosis by inhibiting the expression of GPX4 and DHODH

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