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The targeted therapy of CL dysfunction through post-transcriptional adjustments can be achieved by altering miRNA expression using mimics or antagomirs

Besides, the treatment improved the expressions of MMP-2 and MMP-9, TIMP-1 and TIMP-2 (tissue inhibitor of metalloproteinase) suggesting neuroprotection [50]

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These findings indicate that PCOS and obesity affect insulin sensitivity, and their coexistence might worsen insulin resistance