By binding to ER in endothelial cells, estrogens induce nitric oxide (NO) release, consequently producing vasodilation (Penotti et al., 1996), and the impedance of this flow appears to be reduced after starting hormone (estrogen) replacement therapy (HRT) ( Estrogens and Neurodegenerative Diseases Experimental and clinical data suggest that estrogens have protective effects against neurodegenerative diseases (Vail and Roepke, 2019)
doi: 10.3389/fnins.2021.584649 Received 17 July 2020 Accepted 04 March 2021 Published 11 May 2021 Volume 15 - 2021 Edited by Marco Solmi, University of Padua, Italy Reviewed by Kenji Hashimoto, Chiba University, Japan
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