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Sepiapterin is a stable precursor in the salvage pathway of BH 4 biosynthesis, which converts sepiapterin to BH 4 via the activities of sepiapterin reductase and DHFR (Figure 8)

Antioxidants 7 , 179 (2018)

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It has been observed that in high doses it can trigger or even worsen outbreaks of acne Conclusion: Vitamin B12 and Acne The exact causes of vitamin B12 acne are still unclear

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Individual tolerance and biomarker status significantly influence optimal dosing