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Colby is also the Founder of and the author of Outsmart Your Genes

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While high-dose oral B12 (1,000 mcg daily) may be effective in some cases, intramuscular hydroxocobalamin remains the standard NHS practice

Contraindications may be absolute (life threatening) or relative (higher risk of complications in which benefits may outweigh risks)

A multicenter trial in Alzheimers disease found no benefit on cognitive or functional outcomes while shifting some biomarkers, a smaller trial in healthy older adults reported improved memory and hippocampal connectivity, and the overall assessment is that it is unlikely to help most healthy adults and that the evidence is not conclusive