Different from the old analysis, we used a simplified reference tissue model (see the section Methods), which does not rely on arterial input function, an approach that is potentially beneficial for eliminating another source of variability (i.e., measurement errors in arterial input function) in the kinetic modeling of PET data [84]
The proposed indications for use of the Leadless Dual Chamber System include all four of the following: (1) Rate-Modulated Pacing is indicated for patients with chronotropic incompetence, and for those who would benefit from increased stimulation rates concurrent with physical activity
Afinogenova, Y., Danve, A
Cogn Behav Neurol 26:1422
The concern is theoretical and mechanistic: Dihexa's proposed action is potentiation of hepatocyte growth factor (HGF) signaling at the c-Met receptor, a growth, proliferation, and angiogenesis pathway that is dysregulated in several cancers
It typically presents as macrocytic megaloblastic anemia and neurological impairments, including sensory and motor disfunctions, predominantly in the lower extremities, ataxia, and in more advanced stages cognitive decline progressing to dementia, as well as psychiatric disturbances (Green et al., 2017)
