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Although epidemiologic studies have shown an association between vascular disease and hyperhomocysteinemia, large randomized controlled trials have shown that lowering homocysteine levels in these patients does not reduce the number of myocardial infarctions or strokes, or improve mortality rates

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[DOI] [PubMed] [Google Scholar] 44.Haemmerle G, Zimmermann R, Hayn M, Theussl C, Waeg G, et al

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