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Patches deliver a steady dose of nicotine and are easier for daily adherence, but may increase fetal nicotine exposure and should be removed overnight

An air freshener formulated with smokers in mind is recommended for best results

The distribution of the nicotine in the mature plant is widely variable: 64% of the total nicotine exists in the leaves, 18% in the stem, 13% in the root, and 5% in the flowers

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During this time, both regions continued to develop their own economies, local governments, and cultural experiences, making each one unique in its own right