Consequently, the proven leishmanicidal effect of IONPs in topical treatments suggests two possible mechanisms: either the free iron resulting from the degradation of the particles reaches the infected areas and act on these macrophages, or the key molecules for parasite control, such as ROS and NO, are generated in more superficial layers and diffuse towards the areas where the parasite is located
However, cell-free DNA (cfDNA) analysis, which overcomes these limitations, can provide direct evidence of residual disease and can be used as a minimally invasive detection method for patients with CRC
Sources: Yoo HC, Yu YC, Sung Y, Han JM
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