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Author contributions NS: Conceptualization, Investigation, Project administration, Writing original draft

When DNA damage is present, p53 is crucial in triggering cell-cycle arrest or promoting programmed cell death (apoptosis) [22]

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Recently, the interest among researchers in the role of non-coding RNAs in the regulation of tumorigenesis and development is growing

This knowledge led to the hypothesis that increased levels of Gsto2 in iSPNs can disrupt AA homeostasis, leading to changes in TH protein levels and increased DA synthesis in striatal projecting mDA neurons that potentially express no or low TH in the adult brain