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research shows no additional benefit above 1 mg daily Important: Doses above 1 mg (1,000 mcg) daily showed no additional metabolic benefits in clinical research

While it has not received FDA approval for therapeutic use, it is available for research purposes and is used in metabolic optimization protocols

If treatment isnt appropriate for you, the provider will not issue a prescription

If you were to take my opinion, there are better alternatives available in the market that can aid you in your weight loss journey, such as Semaglutide and 5-Amino-1MQ

By blocking NNMT, it shifts intracellular NAD+ and S-adenosylmethionine (SAM) levels, two cofactors tied to energy metabolism, redox balance, and gene regulation in laboratory models

Vitamins in Animal and Human Nutrition (2nd ed.)