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A better understanding of this animal model and subset of children with ASD should lead to better insight in mechanisms behind environmentally induced ASD pathophysiology and should provide guidance for developing preventive and symptomatic treatments

Standardizing and recording sample collection times enhances the rigor and reliability of study design

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Temperature- and guanidine hydrochloride (GdnHCl)-induced unfolding of mature and precursor mimic (T399A mutant) forms of BlGGT using CD and emission fluorescence revealed that the mature form was structurally more stable and that both forms displayed an irreversible two-state pattern of thermal unfolding (Yang et al., 2011)

Activated RhoA enhances ROCK activity, promoting phosphorylation of myosin light chain and increasing vascular tension [36]