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Smoking freebase cocaine has the additional effect of releasing methylecgonidine into the user's system due to the pyrolysis of the substance (a side effect which insufflating or injecting powder cocaine does not create)

A 2013 double-blind pilot study by Morgan et al

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Further, the therapies safety is evaluated wherein the acceptability, tolerability, and adverse events are majorly observed, and it sets a clear understanding of the side effects posed by the drug in the trials

Popcorn Lung from Vaping Is Extremely Rare/Non-existent Theres no proven link between modern, legal vaping and popcorn lung in the UK - especially when using tested, compliant e-liquids