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The 24-week trials allowed for assessment of several long-term safety considerations
doi: 10.1002/brb3.1726
Mechanistic themes seen in preclinical research In animal and mechanistic work, AOD-9604 has been associated with: Increased lipolysis (breaking down stored fat) Reduced lipogenesis (reducing fat storage) Interactions with -adrenergic pathways in adipose tissue have been discussed as part of its lipolytic signaling profile (OUP Academic) In obese animal models, AOD-9604 has shown reductions in body weight and body fat and changes consistent with increased fat mobilization
367 It is unclear whether genetic risk operates differently in women and men in the development of Alzheimer's disease or susceptibility to the brain changes of Alzheimer's disease
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