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44 These enzymes contribute to H 2 S and sulfane sulfur species release, highlighting NACs potential role in H 2 S production (Fig

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1 Introduction Migraine, a disorder influenced by genetics and characterized by multiple factors involving neurological, glial, and vascular systems, ranks as the second most debilitating condition worldwide, impacting the health of over one billion individuals globally (1)

This mechanism is critical because neurons have a limited ability to synthesize endogenous GS ( Oxidative stress in the CNS acts as a persistent inflammatory trigger by activating brain-resident immune cells, particularly microglia and astrocytes