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rare complications include allergic reactions and hypokalaemia during treatment of severe anaemia
Researchers observed that upon binding the IRR, ARA-290 initiates signaling through JAK2 and downstream pathways including STAT3 and NF-B modulation, distinct from the STAT5-dominant signaling of classical EPO receptor activation
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Explore tissue repair peptides for comprehensive mechanism understanding
de la Vega, E., OLeary, N.A., Shockey, J.E., Robalino, J., Payne, C., Browdy, C.L., et al., Mol
Thats a mechanistically different target than NSAIDs (nonsteroidal anti-inflammatory drugs), or corticosteroids, which partly explains why the compound has attracted interest in cases where conventional anti-inflammatory approaches have failed or created downstream problems
