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Endothelial BMAL1 decline during aging leads to bone loss by destabilizing extracellular fibrillin-1

Immunolocalization studies with double staining for aquaporin-4 and glial fibrillary acidic protein (GFAP), which stains astrocytes, show strong colocalization at the level of the BBB

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Age and frailty may also influence tolerability

After SARS-CoV-2 infection, the viremia stage could increase OxS, elevated levels of ROS/inflammation markers (i.e., peroxide, NO, carbonylated proteins, and IL-6) and inflict severe cellular/tissue damage