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The cytokines IL-1, IL-6, IL-13 and IL-22 have been demonstrated to alter intestinal transcription of CLDN2 [27,28,29,30], although the impact this has on subsequent pore pathway permeability has not been fully elucidated

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456,477,479482 This is an exciting area of future study since Mn II -specific DtxRs are found broadly in Gram-positive and Gram-negative bacteria

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