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611 Voltage-gated sodium and calcium channel blockers VX-150: A pro-drug of a highly selective NaV1.8 inhibitor

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Figure 6 Reactive electrophiles, such as monobromobimane are detoxified by direct conjugation to BSH or by conjugation reactions catalyzed by BSH S -transferases

The lack of FDA approval for human use and the need for higher doses in some experimental settings underscore the importance of evaluating safety and efficacy under strict medical supervision