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Lancet 387 , 679690 (2016)

FIGURE 4 3.4 Nitazoxanide reduced apoptosis in rats with MTX-hepatotoxicity MTX significantly induced hepatic apoptosis as demonstrated by increased proapoptotic markers, Bax level, and caspase-3 activity (Figures 5A, D) while reduced antiapoptotic Bcl-2 level (Figure 5B) and increased Bax/Bcl-2 ratio (Figure 5C) compared to CTRL group

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Therapeutic targets for inflammatory bowel disease: proteome-wide Mendelian randomization and colocalization analyses

Overall, the treatment was well-tolerated, all TRAEs were reversible through symptomatic interventions, and neither SAE nor dose-limiting toxicity (DLT) occurred

Present in reduced (unoxidized form)