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2016;5:e10903

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This delivery method ensures rapid absorption and maximum effectiveness , compared to oral supplements that often lose potency through digestion

5.3 Remodeling of the immune microenvironment In the immune combination strategy to address gemcitabine resistance, CD40 agonist activation of antigen presentation and oncolytic virus-induced viral mimicry to enhance immunogenic cell death (ICD) are two key directions, which can enhance the efficacy of chemotherapy and reverse resistance by reshaping the immune microenvironment: CD40 agonists (such as Selicrelumab) promote tumor antigen presentation and T cell activation by activating CD40 receptors on the surface of dendritic cells (Vonderheide, 2020), and form an antigen release-presentation-response closed loop when combined with gemcitabine

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