Bolton WD, Hofstetter WL, Francis AM, Correa AM, Ajani JA, Bhutani MS, Erasmus J, Komaki R, Maru DM, Mehran RJ, Rice DC , Roth JA, Vaporciyan AA, Walsh GL, Swisher SG
FIGURE 7 7 Discussion 7.1 Limits of preclinical models and translational relevance While a growing body of preclinical evidence supports the therapeutic potential of redox-targeted antioxidants and stem cellderived EVs in mitigating oxidative stress and restoring ovarian function, significant translational hurdles remain before these strategies can be applied clinically in women
Most pathways can be related to the pathogenesis of Alzheimers Disease
This was observed after 3 days of treatment (Nasca et al., 2013)
They then ask clinicians about safety and dosing
Others, like Metformin or Bupropion, may be prescribed off-label based on your providers clinical judgment