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Patrinos, University of Patras, Greece Reviewed by Magorzata Borczyk, Polish Academy of Sciences, Poland Joaquim Carreras, Tokai University, Japan Updates Copyright 2023 Zhu, Lian, Wang, Wang, Pang, Xu, Wang, Li, Ji and Lu

Neuroscience 284, 290296

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MPP + treatment significantly reduces TIGAR expression in HT22 cells, downregulates NADPH, GPX4, and GSH levels, upregulates GSSG levels and the GSSG/GSH ratio, decreases adenosine triphosphate (ATP) production, and promotes neuronal ferroptosis, iron-dependent lipid peroxidation, and mitochondrial dysfunction, thereby exacerbating neuronal cytotoxicity

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On that basis, there was a large daily loss of chromium (88% of the RDA) and potassium (57% of the RDA)