Six months of voluntary wheel running significantly downregulated the expression of Ferritin, HO-1, janus kinase 1 (JAK1), signal transducer and activator of transcription 3 (STAT3), DMT1, TFR, and hepcidin in the cerebral cortex of five familial Alzheimers disease (5FAD) mice, reduced A and IL-6 levels, inhibited A plaque deposition and neuroinflammation, thereby improving neurological deficits in AD mice ( 2 max significantly downregulated the levels of TFR1, TF, DMT1, FTL, FTH, mitochondrial Ferritin, -secretase, and APP in the cortical motor regions of aged amyloid precursor protein-C105 (APP-C105) mice, upregulated the expression of FPN1, Furin, and -secretase, significantly reduced Fe 2+ , Fe 3+ , and total iron content, inhibited brain iron accumulation and A plaque growth, thereby improving learning ability, memory, and cognitive function in aged APP-C105 mice (Choi et al., 2021)
95 The virome functions differently in the healthy lung than in the disease state, or even the opposite
10.1172/jci.insight.90777 JCI Insight 55 LiddellJ
He Q, Liu C, Wang X et al (2023) Exploring the mechanism of curcumin in the treatment of colon cancer based on network pharmacology and molecular docking
Ginsenoside 25-OCH(3)-PPD promotes activity of LXRs To Ameliorate P2X7R-Mediated NLRP3 inflammasome in the development of hepatic fibrosis
Rahm opens up about the challenges of being a female leader in a male-dominated health industry and her ongoing mission to uplift and empower women around the world
