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The researchers successfully constructed the cBEST gene editing system by knocking out three restriction endonuclease genes in Bifidobacterium [100]

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[1] [6] Severe deficiencies may include symptoms of reduced heart function, suppression of bone marrow, as well as more various severe neurological symptoms possibly including sensory loss, abnormal balance and reflexes, memory and consciousness impairment, smell and taste problems, depression, irritability, confusion, and psychosis