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Experimental models demonstrate that high-dose testosterone administration increases hepatic reactive oxygen species production while suppressing endogenous antioxidant enzyme activity ( Intrahepatic cholestasis observed in anabolic steroid users has been linked to impaired bile-acid transport

For LCMS analysis, metabolite extracts were analysed by high-resolution mass spectrometry with an Orbitrap Exploris 240 (Thermo) coupled to a Vanquish Flex liquid chromatography system (Thermo)

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Table 4 summarizes signaling pathways reported in relation to HTY exposure across different cancer models

Integrating these gut health-focused strategies into clinical practice could transform the management of ME/CFS, fostering a more holistic perspective on the condition that places emphasis on underlying biological mechanisms [5, 10, 15]

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