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A dose-dependent inhibition of the PbGST was observed with increasing concentrations of CB-27, suggesting that the compound blocks GST enzyme activity (Figure 4A)

The trial met its primary endpoint, demonstrating statistically significant and superior weight loss with CagriSema versus placebo

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doi: 10.1016/j.lfs.2013.03.016 [DOI] [PubMed] [Google Scholar] 159.Wang C, Chen YW, Zhang L, et al