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While multiple compounds and approaches have been suggested in the preclinical setting as potential treatments for SCA3 [174, 178], little has translated to clinical studies, which is clear by the small number of interventional trials carried out so far

Similarly, individuals whose lesions show high expression of senescence markers like p16INK4a or SA--Gal activity might be prioritized for senolytic treatments, ensuring a more personalized and effective approach

Catching and correcting a confirmed deficiency early is generally simpler and less costly than treating the complications that a long-standing deficiency can cause

Using intravenous vitamin B12 shows how different treatments are used around the world

LA-12: A methylcobalamin formulation commonly used for energy support

It may lead to symptoms, such as difficulty breathing, rashes, wheezing, vomiting, itching, sneezing, etc