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342 Moreover, a considerable number of patients with T2D also have hyperuricemia, which is also a cause of CKD

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However, it is necessary to directly study muscle cells, since there are key differences in the signalling and trafficking machinery between adipocytes and myocytes, for example in the major Rab proteins responsible for insulin-regulated GLUT4 delivery to the cell surface (Rab8a and 13 in muscle [118]

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