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Signaling mechanism(s) of reactive oxygen species in Epithelial-Mesenchymal Transition reminiscent of cancer stem cells in tumor progression

NF-B pathway inhibition: Nuclear factor kappa B (NF-B) is master transcription factor regulating inflammatory gene expression

After 48 h, biofilms were washed once with 1 PBS followed by treatment with different concentrations of 0, 5, 10, 25, and 50 M H 2 O 2 (prepared by diluting an aliquot of 30% (v/v) H 2 O 2 in 1 PBS) for 24 h, at 37C and shaking at 150 rpm

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Furin structure/function Furin is a 794-AA type-1 transmembrane (TM) protein with large luminal and extracellular regions, a common feature among PC enzymes

There is no pharmacological reason to separate the timing beyond using separate injection sites