We used number of cardiovascular disease incidents, as opposed to risk factors
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Estimated daily intake (EDI), hazard quotient (HQ), hazard index (HI), and target cancer risk (TCR) were calculated based on oral (buccal) exposure scenarios at absorption fractions of 6%, 20%, 25%, and 100%
These observations indicate a deterministic shift of healthy oral microbiome during environmental stress conditions, like tobacco consumption, to a more dispersed microbial community composition in tobacco consuming individuals that is similar to the microbiome associated with OSCC buccal site ( Figure 7 )
On the other hand, excessive ROS might react with nucleic acid, lipids, carbohydrates, and protein causing inflammation and oxidative stress that are the main causes for the development of various metabolic disorders
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