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Strictly enteral administration (directly into the intestines) can be used for systemic administration, as well as local (sometimes termed topical), such as in a contrast enema, whereby contrast media are infused into the intestines for imaging

A more individualized response-based approach monitors body composition changes and continues therapy as long as positive progress occurs, adjusting or pausing when plateaus develop or goals are achieved

GLP-1-based therapies should be used with caution in pregnancy or breastfeeding, and the risk of hypoglycaemia is increased when these agents are used alongside insulin or sulfonylureas

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