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While it inhibits fibrosis by activating the Keap1-Nrf2 pathway and downregulating the phosphorylation of Smad3 and STAT3, the interactions among involved signaling pathways (such as PI3K/Akt, MAPK, TGF-, Wnt/-catenin) and their roles at different pathological stages have not been systematically studied

Unlike injections, it does not require general anaesthesia and allows patients to resume their regular activities right after the procedure

They found that SLC7A11 acts not only as a protective shield against oxidative stress, but also as a suit of armour, controlling the cytoskeleton of the cancer cells a structure that helps them become mobile and aggressive

Biochemistry 42: 1331913330

Y., Kim, Y

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