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-mangostin treats early-stage adjuvant-induced arthritis of rat by regulating the CAP-SIRT1 pathway in macrophages

Aydin AF, Kusku-Kiraz Z, Dogru-Abbasoglu S, Uysal M

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Ferroptosis antioxidant defense system mainly divided into GPX4-dependent systems (SLC7A11/GSH/GPX4 axis) and GPX4-non-dependent systems (FSP1-CoQ10-NAD(P)H axis, GCH1/BH4 axis, and DHODH/CoQH2 axis) [31, 32] (Fig