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The panel cited the high rate of acute kidney injury (AKI) in patients assigned to the treatment group, which it said could potentially be attributed to ITCA 650

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Tong TYN, Appleby PN, Bradbury KE, Perez-Cornago A, Travis RC, Clarke R, Key TJ

doi:10.1136/JNNP-2012-303068 14

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2 Pathogenesis of Fibromyalgia The fact that pain is the hallmark of fibromyalgia has caused experts to believe that the disorder is neurogenic in origin, as it is associated with a central amplification of pain perception characterized most prominently by hyperalgesia (increased response to painful stimuli) and allodynia (pain from stimuli not normally painful)