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Other reported effects include headaches, dizziness, nausea, and gastrointestinal discomfort, though these are less common

Research shows that low serum vitamin B-12 levels are linked to decreased bone density, which can lead to fragile bones and a higher risk of osteoporosis

A reasonable bar would be at least one phase 2 RCT in a clinically relevant population (cognitive impairment, mild Alzheimer disease, post-stroke recovery, or similar) showing clinical efficacy with acceptable safety

doi: 10.1002/prp2.70133 207 McMullenMKarakasisKMadariagaAOzaAM

A public docket has not been made available for the latter meeting.