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Moreover, theaflavin - through p53 pathways - can downregulate glycolysis and angiogenesis - suppressing vascular-endothelial growth factor (VEGF) expression -, promoting apoptosis through Bcl-2 inhibition [137]

Additionally, the Gln27 mutation (a polymorphism in the B2dR genes) has been associated with adolescent ME/CFS (78)

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It is interesting to note the effect of metformin [50, 332,333,334], which is a first line diabetes II drug and has been shown to increase healthy life span irrespective of its anti-diabetes effect

once reconstituted, refrigerate at 28 C and do not freeze