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I was down 5 lbs after 4 weeks
The answer depends on several factors and requires some careful timing
From the observations above we infer that when recovery is interpreted from a GSH viewpoint (see below as well, Implications for clinical therapy), a substantive recovery can be claimed to occur only once GSH has improved past its half-maximal threshold
Atorvastatin use also reduces HSC activation via the production of sterol regulatory element-binding protein 1 (SREBP1) and peroxisomal proliferator-activated receptor (PPAR) (Marinho et al., 2017), in addition to the reduction in fibrosis and portal hypertension via non-canonical Hedgehog signaling (Uschner et al., 2015)
Although published studies and reviews discuss promising activity in preclinical models, available human data remain limited, and findings from animal or cell studies should not be directly translated into human outcomes
And right now, the vial is telling the more important story.
