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This is not only due to the effects of nicotine, she notes, but also to the humectants (glycerine and glycerol), different flavourings and other constituents of e-cigarettes, which have been shown to increase free radical attack and inflammation in the skin." People who vape will also be at high risk of clotting problems, infections and poor cell regeneration, says Dr Khorana, adding that "in recent years, there has also been an increase in the number of contact dermatitis cases associated with vape use." Does vaping inflame your face