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This provides an objective biomarker of dysfunction even when structural imaging is normal [3]
Although gastrointestinal tolerability was not explicitly evaluated, metformin is associated with such adverse effects in clinical settings, a factor relevant for translational consideration
4) Integrate multi-disciplinary approaches for clinical translation: Combine artificial intelligence (AI)-driven drug discovery (e.g., machine learning models to predict ferroptosis modulator efficacy using multi-omics data) with network pharmacology to identify synergistic drug combinations (e.g., ferroptosis inhibitors + anti-fibrotic agents)
