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Planchart et al., 2018)

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Unlike PROTACs, molecular glues do not require a linker and can directly induce contact between transcription factors and E3 ligases, offering a simpler architecture and easier optimization

indica downregulated expressions of genes encoding enzymes for ascorbate synthesis in Arabidopsis thaliana (Vadassery et al., 2009)

Its not uncommon for clients to move through the remove and replace stages without feeling dramatically different