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They are subject to all the same FDA rules that apply to traditional tobacco products (thanks to the 2016 Deeming Rule), but they also face an additional layer of state and municipal regulations that in many cases specifically target e-cigarettes because of the youth vaping epidemic that emerged between 2018 and 2022

Thus, our data are consistent with FOXN4 regulating this step in early ciliogenesis

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BMJ Open Sport Exerc Med

But that's just the half of it