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104 Pietrzak, D., Kasperek, K., Rkawek, P
Given that sarcopenia is a key component of CHE pathophysiology, it is reasonable to test for CHE in patients with reduced muscle mass or muscle strength [44,45,46]
DOI: 10.1093/jnci/djg051 56
Old age is a factor causing significant changes in pharmacokinetics, mainly at the stage of distribution (increased content of adipose tissue and 1 acid glycoprotein, reduced water content and albumin concentration) and elimination (impaired renal function, slower hepatic metabolism) [153, 366]