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Consequently, the yield was calculated using this purity, 66%, from the concentrations of -EC determined by HPLC analysis using the standard -EC with assumed purity, 100%

Although the majority of prior trials of combination therapy with levothyroxine and liothyronine have not shown patient benefit, these trials were largely underpowered and suffered from shortcomings such as short duration and once-daily liothyronine dosing

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